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KMID : 0043319960190020091
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Archives of Pharmacal Research
1996 Volume.19 No. 2 p.91 ~ p.94
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Ar-turmerone and β-atlantone induce internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia HL-60 cells
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Paek Sang-Hyun
Kim Geon-Joo
Han Seung-Jeong
Yum Sung-Kwan
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Abstract
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In the course of a search for antitumor agents, we found that the extract of Curcuma longa was effective in inducing apoptosis or programmed cell death (PCD) in human myeloid leukemia cells (HL-60). Active compounds for PCD were isolated from the hexanic extraction of the rhizome of Curcuma longa. With the several chromatographies, and spectral data, they were identified as ar-turmerone and . The present results demonstrate that the exposure of human myeloid leukemia HL-60 cells to clinically achievable concentrations of arturmerone (TU) or .(AT) produced internucleosomal DNA fragmentation of approximately 200 base-pair multiples, and the morphological changes characteristic of cells undergoing apoptosis or PCD. This findings suggest that these agents may exert their antitumoral activity, in part, through induction of apoptosis(PCD).
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KEYWORD
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ar-Turmerone, β-atlantone, Anticaner activity, Apoptosis, Programmed cell death
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